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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are often focused on the practical aspects of the study design, such as recruitment and consent, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This kind of heterogeneity, which is vital for pragmatic trials to be valid and 프라그마틱 슬롯체험 reduce bias in results is also essential. However, too much heterogeneity, can cause problems with the trial design.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be used to assess the causality of an intervention and its effects. However, they should not be used to replace explanatory studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace or 프라그마틱 슬롯 체험 complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic study which includes recruitment, design and delivery of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.